Cirrhosis, most frequently caused by hepatitis C or alcoholism, was the 12th leading cause of death in the United States in 2000, accounting for more than 25,000 deaths.1 Ascites is the most common complication of cirrhosis and is associated with a poor quality of life, increased risks of infections and renal failure, and a poor long-term outcome.2,3 In recent years, important advances have been made in the management of cirrhosis and ascites.
Pathophysiology of Ascites
The chief factor contributing to ascites is splanchnic vasodilatation.4 Increased hepatic resistance to portal flow due to cirrhosis causes the gradual development of portal hypertension, collateral-vein formation, and . . .
http://content.nejm.org/cgi/reprint/350/16/1646.pdf
Management of Cirrhosis and Ascites
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